RTECS NUMBER : TT0700000
CHEMICAL NAME : Potassium fluoride
CAS REGISTRY NUMBER : 7789-23-3
LAST UPDATED : 200007
DATA ITEMS CITED : 40
MOLECULAR FORMULA : F-K
MOLECULAR WEIGHT : 58.10
WISWESSER LINE NOTATION : KA F
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Fluorure de potassium
* Potassium fluorure

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 245 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
XEURAQ U.S. Atomic Energy Commission, University of Rochester, Research and
Development Reports. (Rochester, NY) Volume(issue)/page/year: UR-154,1951

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 64 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
XEURAQ U.S. Atomic Energy Commission, University of Rochester, Research and
Development Reports. (Rochester, NY) Volume(issue)/page/year: UR-154,1951

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 40030 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DZZEA7 Deutsche Zahnaerztliche Zeitschrift. (Carl Hanser Verlag, Postfach
860420, D-8000 Munich 86, Fed. Rep. Ger.) V.1- 1946-
Volume(issue)/page/year: 34,484,1979

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals",
11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:
11,1214,1989

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 420 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
Volume(issue)/page/year: 124,133,1937

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 1050 mg/kg
SEX/DURATION : female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
DZZEA7 Deutsche Zahnaerztliche Zeitschrift. (Carl Hanser Verlag, Postfach
860420, D-8000 Munich 86, Fed. Rep. Ger.) V.1- 1946-
Volume(issue)/page/year: 34,484,1979

** MUTATION DATA **

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - rat Bone marrow
DOSE/DURATION : 100 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 343,67,1995

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 500 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 187,165,1987

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 400 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 187,165,1987

*** REVIEWS ***

ACGIH TLV-TWA 2.5 mg(F)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1999

ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1999

TOXICOLOGY REVIEW
AMSSAQ Acta Medica Scandinavica, Supplement. (Almqvist & Wiksell, POB
45150, S-10430 Stockholm, Sweden) No.1-730, 1921-88.
Volume(issue)/page/year: 400,5,1963

*** U.S. STANDARDS AND REGULATIONS ***

MSHA STANDARD-air:TWA 2.5 mg(F)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,116,1971

OSHA PEL (Gen Indu):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994

OSHA PEL (Construc):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994

OSHA PEL (Shipyard):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993

OSHA PEL (Fed Cont):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-AUSTRALIA: TWA 2.5 mg(F)/m3, JAN1993

OEL-AUSTRIA: MAK 2.5 mg(F)/m3, JAN1999

OEL-BELGIUM: TWA 2.5 mg(F)/m3, JAN1993

OEL-FINLAND: TWA 2.5 mg(F)/m3, JAN1999

OEL-FRANCE: VME 2.5 mg(F)/m3, JAN1999

OEL-GERMANY: MAK 2.5 mg(F)/m3, JAN1999

OEL-HUNGARY: TWA 1 mg(F)/m3, STEL 2 mg(F)/m3, JAN1993

OEL-THE NETHERLANDS: MAC-K 3.5 mg(F)/m3, JAN1999

OEL-NORWAY: TWA 0.6 mg(F)/m3, JAN1999

OEL-THE PHILIPPINES: TWA 2.5 mg(F)/m3, JAN1993

OEL-POLAND: MAC(TWA) 1 mg(HF)/m3, MAC(STEL) 3 mg(HF)/m3, JAN1999

OEL-SWEDEN: NGV 2 mg(F)/m3, JAN1999

OEL-SWITZERLAND: MAK-W 1.8 ppm (1.5 mg(F)/m3), KZG-W 3.6 ppm (3.0 mg(F)/m3),
JAN1999

OEL-THAILAND: TWA 2.5 mg(F)/m3, JAN1993

OEL-TURKEY: TWA 2.5 mg(F)/m3, JAN1993

OEL-UNITED KINGDOM: LTEL 2.5 mg(F)/m3, JAN1993

OEL IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV;

OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO FLUORIDES, INORGANIC-air:10H TWA 2.5 mg(F)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 60410
No. of Facilities: 1661 (estimated)
No. of Industries: 42
No. of Occupations: 33
No. of Employees: 8493 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 60410
No. of Facilities: 1419 (estimated)
No. of Industries: 37
No. of Occupations: 29
No. of Employees: 22283 (estimated)
No. of Female Employees: 3192 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy

EPA TSCA Section 8(b) CHEMICAL INVENTORY